沙立度胺治療多發(fā)性骨髓瘤、骨髓增生異常綜合征和骨髓纖維化療效觀察.pdf

1、中國協和醫(yī)科大學碩士學位論文沙立度胺治療多發(fā)性骨髓瘤、骨髓增生異常綜合征和骨髓纖維化療效觀察姓名：高輝申請學位級別：碩士專業(yè)：內科學指導教師：肖志堅20070501中國醫(yī)學科學院中國協和醫(yī)科大學Abstract【objective]Toexploretheoutcomeandsideeffectofthalidomideinthei_eaUnentofmultiplemyeloma(MM)，myelodysplasticsyndrome

2、sfMDS)andmyelofibrosis(MF)[Methods]PatientsinSixthdepartmentofHematology，ChineseAcademyofMedicalScienceandPekingUnionMedicalCollegeInstituteofHematologyfromJanuary2001toFebruary2007we陀enrolledincluding22casesofmultiplemy

3、eloma25casesofmyelodysplesticsyndromesand15casesofmyelofibrosisTheouleomeandsideeffectsWelgevaluated[ResuU]Aneffectiverateof727％wasobservedinmultiplemyelomagroupwithaCRrateof318％andaPRrateof409％respectivelyTheeffectivera

4、teofmyelodysplasticsyndromesgroupwas72O％。withHIE60／0ⅡN200／。HI—P12％respectivelyHIEshowedatrendofsuperiorityingroupINTIthaningroup1NT2，whichneedfultherevaluationwithlargersampleNosignificanceofdifferenceWasfoundbetweenthet

5、wogroupsinca∞ofHINandHIPbothofwhichwerelowThalidomideWaslesseffectiveintheameliorationofdisordersofgranulocytesandplatelets11七effectiverateinthemyeloflbresisgroupis71％Sideeffectsobservedinthe54casesarelistedasthefollowin

6、g：sensitivetroubles19黜(35％)，sedation18cases(333％)，constipation18cas∞(333％)，peripheral12cases(222％)。thrombosisonlyonecaseAllthesideeffectsweremildandwelltolerated，with$onmseverecase$，whichreleasedwithther2ascofdrug[Conclu

7、sions]Thalidomideiseffectiveinthetreatmentofmultiplemyelomamyelodysplasticsyndromesandmyelofibrosis，withmildandreversiblesideeffect[Keywords]Thalidomide；multiplemyeloma；myelodysplasticsyndromes；myelofibrosis；effect：sidee